인슐린으로 조절되는 당뇨쥐 상악에서 발치 후 즉시 임플란트 주변에서 골형성
Bone response around immediately placed titanium implant in the extraction socket of diabetic and insulin-treated rat maxilla
김대원, 허현아, 임상규, 이원, 김영실, 표성운,
소속 상세정보
김대원 ( KIm Dae-Won ) - 가톨릭대학교 임상치과학대학원 구강악안면외과학과
허현아 ( Heo Hyun-A ) - 가톨릭대학교 의과대학 치과학교실 구강악안면외과
임상규 ( Lim Sang-Gyu ) - 가톨릭대학교 의과대학 치과학교실 구강악안면외과
이원 ( Lee Won ) - 가톨릭대학교 임상치과학대학원 구강악안면외과학과
김영실 ( Kim Young-Sil ) - 제주대학교 의과대학 병리학교실
표성운 ( Pyo Sung-Woon ) - 가톨릭대학교 의과대학 치과학교실 구강악안면외과
KMID : 0355620110370010030
Abstract
Introduction: Dental implants are used routinely with high success rates in generally healthy individuals. By contrast, their use in patients with diabetes mellitus is controversial because altered bone healing around implants has been reported. This study examined the bone healing response around titanium implants placed immediately in rats with controlled and uncontrolled diabetes.
Materials and Methods : Twenty rats were divided into the control, insulin-treated and diabetic groups. The rats received streptozotocin (60 mg/kg) to induce diabetes; animals in the insulin-treated group also received three units of subcutaneous slow-release insulin. A titanium implant (1.2×3 mm) was placed in the extraction socket of the maxillary first molar and bone block was harvested at 1, 2 and 4 weeks.
Results: Bone formation around the implants was consistently (from 1 to 4 week post-implantation) slower for the diabetic group than the control and insulin-treated group. Bone morphogenesis in the diabetic rats was characterized by fragmented bone tissues and extensive soft tissue intervention.
Conclusion: The immediate placement of titanium implants in the maxilla of diabetic rats led to an unwanted bone healing response. These results suggest that immediate implant insertion in patients with poorly controlled diabetes might be contraindicated.
키워드
Diabetes mellitus; Dental implants; Insulin; Bone remodeling; Osseointegration
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